Abstract
A crystalline biohybrid with a 4 : 1 protein : cucurbituril mass ratio is presented. This result was achieved by engineering additional cucurbit[7]uril (Q7) binding sites into a β-propeller protein. In contrast to the parent protein, Q7-controlled assembly of the engineered variant occurred in solution, as evidenced by NMR and SAXS measurements.
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / chemistry*
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Bacterial Proteins / metabolism
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Binding Sites
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Bridged-Ring Compounds / chemistry*
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Bridged-Ring Compounds / metabolism
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Imidazoles / chemistry*
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Imidazoles / metabolism
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Lectins / chemistry
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Lectins / genetics
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Lectins / metabolism
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Nuclear Magnetic Resonance, Biomolecular
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Ralstonia solanacearum / metabolism
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Scattering, Small Angle
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X-Ray Diffraction
Substances
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Bacterial Proteins
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Bridged-Ring Compounds
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Imidazoles
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Lectins
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cucurbit(7)uril