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Elife. 2019 Dec 11;8. pii: e49542. doi: 10.7554/eLife.49542.

Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice.

Author information

1
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
2
Center for Systems Biology Dresden, Dresden, Germany.
3
Cluster of Excellence, Physics of Life, Technische Universität Dresden, Dresden, Germany.
4
Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany.
5
Department of Computer Science, Technische Universität Dresden, Dresden, Germany.
6
Biozentrum, Ludwig Maximilians Universität, München, Germany.

Abstract

Rod photoreceptors of nocturnal mammals display a striking inversion of nuclear architecture, which has been proposed as an evolutionary adaptation to dark environments. However, the nature of visual benefits and the underlying mechanisms remains unclear. It is widely assumed that improvements in nocturnal vision would depend on maximization of photon capture at the expense of image detail. Here, we show that retinal optical quality improves 2-fold during terminal development, and that this enhancement is caused by nuclear inversion. We further demonstrate that improved retinal contrast transmission, rather than photon-budget or resolution, enhances scotopic contrast sensitivity by 18-27%, and improves motion detection capabilities up to 10-fold in dim environments. Our findings therefore add functional significance to a prominent exception of nuclear organization and establish retinal contrast transmission as a decisive determinant of mammalian visual perception.

KEYWORDS:

Chromatin organisation; biophysics; cell biology; mouse; optics; physics of living systems; retina; vision; visual ecology

PMID:
31825309
DOI:
10.7554/eLife.49542
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