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Curr Pharm Des. 2019;25(45):4763-4770. doi: 10.2174/1381612825666191210152156.

Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC.

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Centro de Biología Molecular "Severo Ochoa". CSIC-UAM. Nicolás Cabrera 1, 28049 Madrid, Spain.
Research Group of Neurodegenerative Diseases, Department of Animal Health, Faculty of Veterinary Medicine and Zootechnics - Tolima University, Santa Helena - 730006299, Ibagué, Colombia.
Departamento de Biología (Fisiología Animal). Facultad de Ciencias. Universidad Autónoma de Madrid. C/Darwin 2. 28049 Madrid, Spain.
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.


Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage occurs due to the lack of nutrients and oxygen contributed by the blood flow. The present review aims to analyze to what extent the lack of each of the elements of the system leads to damage and which mechanisms are unaffected by this deficiency. We believe that the specific analysis of the effect of lack of each component could lead to the emergence of new therapeutic targets for this important brain pathology.


AMPK; Middle Cerebral Artery Occlusion (MCAO); Oxygen-glucose Deprivation (OGD); Stroke; mTORC1; nutrients deprivation; signaling.

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