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Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165612. doi: 10.1016/j.bbadis.2019.165612. Epub 2019 Dec 6.

Current nutritional and pharmacological anti-aging interventions.

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Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Alcorcón, 28922, Madrid, Spain. Electronic address:
Centro de Biología Molecular Severo Ochoa UAM-CSIC, Facultad de Ciencias Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain.


Aging is the main risk factor for chronic diseases and disablement in human societies with a great impact in social and health care expenditures. So far, aging and, eventually, death are unavoidable. Nevertheless, research efforts on aging-associated diseases with the aim not only to extend life span but also to increment health span in an attempt to delay, stop and even reverse the aging process have not stopped growing. Caloric restriction extends both health and life span in several short-lived experimental models and has brought to light the role of different molecular effectors involved in nutrient sensing pathways and longevity. This opens the possibility of modulating these molecular effectors also in humans to increase longevity and health span. The difficulty to implement caloric restricted diets in humans has led to the development of new bearable diets such as time-restricted feeding, intermittent fasting or diets with limited amounts of some nutrients and to the search of pharmacological agents, targeted to the effectors that mediate the extension of life and health span in response to these anti-aging diets. Pharmacological approaches that eliminate senescent cells or prevent primary causes of aging such as telomere attrition also emerge as potential anti-aging strategies. In the present article, we review these possible nutritional and pharmacological interventions designed to mitigate and/or delay the aging process and to increase health and life span.


Aging; Anti-aging diets; Anti-aging treatments; Caloric restriction; Health span; Longevity

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