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Pak J Pharm Sci. 2019 Sep;32(5):2155-2162.

Development of biodegradable sustained-release damnacanthal nanocapsules for potential application in in-vitro breast cancer studies.

Author information

1
Institute of Community health Development (i-CODE), Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, Malaysia.
2
Institute of Community health Development (i-CODE), Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, Malaysia/Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, Malaysia.
3
Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Nerus, Terengganu, Malaysia.
4
School of Ocean Engineering, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, Malaysia.
5
Faculty of Pharmacy, Cyberjaya University College of Medical Sciences, Jalan Teknokrat 3, Cyber 4,Cyberjaya, Selangor, Malaysia.
6
Faculty of Pharmacy, International Islamic University Malaysia, Pahang, Malaysia.

Abstract

The "noni" species of Morinda citrifolia L., is using in traditional medicine in the tropical country for over 2000 years. Noni fruit has come from the Morinda citrifolia tree which is called Rubiaceae, and it is from the coffee family. It is a perennial herb whose ripe fruit has a robust butyric acid smell and flavor. Recently scientists have proven that this fruit has antioxidant and antibiotic properties in vitro. An anthraquinone, damnacanthal, is one of the constituents of Morinda citrifolia. It has been demonstrated to have anti-cancer properties. Damnacanthal has low water solubility and low bioavailability. Formulating of damnacanthal into the biodegradable nanocapsule drug delivery system may increase its bioavailability. Various formulations of damnacanthal would be developed to enable the selection of a dosage form that could offer the provision of the anti-cancer bioactive substance with suitable sustained- or controlled release properties. The efficiency of extraction of damnacanthal will be compared using both conventional and traditional method. Both the damnacanthal and an anthraquinone active compounds extracted from noni roots, are currently being studied in the context of anti-cancer study. Soon, the medical values, bioactivities and nutritional of this fruit can be assessed, especially its anti-cancer activity, this fruit extract could play an outstanding economic role in Malaysia and other tropical countries.

PMID:
31813882

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