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Rev Med Interne. 2020 Feb;41(2):123-125. doi: 10.1016/j.revmed.2019.11.005. Epub 2019 Dec 5.

[Intake of high dose biotin: A cause of artificial hyperthyroidism].

[Article in French]

Author information

1
Service d'endocrinologie, diabétologie et maladies métaboliques, centre hospitalier universitaire, 21079 Dijon, France; Unité Inserm LNC-UMR 1231, université de Bourgogne, 21000 Dijon, France. Electronic address: benjamin.bouillet@chu-dijon.fr.
2
Service d'endocrinologie, diabétologie et maladies métaboliques, centre hospitalier universitaire, 21079 Dijon, France; Unité Inserm LNC-UMR 1231, université de Bourgogne, 21000 Dijon, France.

Abstract

INTRODUCTION:

Many hormone immunoassays use the biotin streptavidin interaction to immobilize immune complexes. The intake of high dose biotin can interfere with immunoassays using the biotin streptavidin interaction. The biotin-immunoassay interference generates falsely low or falsely high tests of hormones according to the type of immunoassay used.

CASE REPORT:

A 70-year-old patient, with progressive multiple sclerosis, was referred to our hospital for thyrotoxicosis. She was found to have markedly elevated thyroid hormones level (T3-T4) and decreased thyrotropin (TSH) level but she had no symptoms of hyperthyroidism. An ingestion of biotin, that is more and more frequent in patients with progressive multiple sclerosis, was found. Thyroid function tests normalized after discontinuation of biotin treatment.

CONCLUSION:

The discrepancy between a clinical exam which is not indicative of thyrotoxicosis and markedly abnormal thyroid function tests should lead to a search for biotin intake, which can interfere with thyroid function tests.

KEYWORDS:

Biotin; Biotine; Hyperthyroidism; Hyperthyroïdie; Immunoassay; Immunodosages; Interference; Interférence

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