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J Vet Cardiol. 2019 Dec;26:51-62. doi: 10.1016/j.jvc.2019.11.003. Epub 2019 Nov 14.

Comparison between the effects of torsemide and furosemide on the renin-angiotensin-aldosterone system of normal dogs.

Author information

1
Department of Clinical Sciences, Colorado State University, Campus Delivery 1678, Fort Collins, CO, 80523, USA.
2
Department of Clinical Sciences, Colorado State University, Campus Delivery 1678, Fort Collins, CO, 80523, USA. Electronic address: marisa.ames@colostate.edu.
3
Department of Statistics, Colorado State University, 102 Statistics Building, Fort Collins, CO, 80523, USA.
4
Attoquant Diagnostics GmbH, Campus Vienna Biocenter 5, 1030 Vienna Austria.

Abstract

INTRODUCTION/OBJECTIVES:

We hypothesized that torsemide and furosemide, at approximately equipotent dosages (similar diuresis), would have comparable effects on the circulating renin-angiotensin-aldosterone system.

ANIMALS, MATERIALS AND METHODS:

Six, healthy, middle-aged, male Beagles were randomized to receive torsemide (0.1 mg/kg PO q 12 h), furosemide (2.0 mg/kg PO q 12 h), or placebo for 10 days during three separate periods, separated by a 10-day washout period, in a crossover design. Blood was collected on days 1, 5, and 9 and 24-h urine collection ended on days 2, 6, and 10. After repeated measures analysis and Bonferonni correction, variables with an adjusted p<0.05 were investigated further, using Tukey's method.

RESULTS:

Twenty-four-hour urine production differed significantly between the diuretics only on day 10, with torsemide causing a 38% greater diuresis than furosemide. There was, however, no significant difference in average 3-day diuresis. There were no significant differences between diuretics in the 24-h urinary excretion of sodium, chloride, or potassium, though furosemide caused less kaliuresis than torsemide. Serum renin, angiotensin II, and aldosterone and the urine aldosterone-to-creatinine ratio were significantly increased in the diuretic groups, as compared to placebo on days 5/6 and 9/10. There were no significant differences in these values between diuretics. Creatinine and blood urea nitrogen concentrations rose comparably in the diuretic groups, remaining within reference intervals in all dogs.

CONCLUSIONS:

At approximately equipotent dosages (20:1), torsemide and furosemide produced comparable renin-angiotensin-aldosterone system activation. Torsemide's similar potassium excretion profile to furosemide decreases support for a hypothesized mineralocorticoid-receptor blocking capability.

KEYWORDS:

Congestive heart failure; Diuretics; Kaliuresis; Urine aldosterone to creatinine ratio

PMID:
31809955
DOI:
10.1016/j.jvc.2019.11.003
[Indexed for MEDLINE]

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