Send to

Choose Destination
J Vet Cardiol. 2019 Dec;26:51-62. doi: 10.1016/j.jvc.2019.11.003. Epub 2019 Nov 14.

Comparison between the effects of torsemide and furosemide on the renin-angiotensin-aldosterone system of normal dogs.

Author information

Department of Clinical Sciences, Colorado State University, Campus Delivery 1678, Fort Collins, CO, 80523, USA.
Department of Clinical Sciences, Colorado State University, Campus Delivery 1678, Fort Collins, CO, 80523, USA. Electronic address:
Department of Statistics, Colorado State University, 102 Statistics Building, Fort Collins, CO, 80523, USA.
Attoquant Diagnostics GmbH, Campus Vienna Biocenter 5, 1030 Vienna Austria.



We hypothesized that torsemide and furosemide, at approximately equipotent dosages (similar diuresis), would have comparable effects on the circulating renin-angiotensin-aldosterone system.


Six, healthy, middle-aged, male Beagles were randomized to receive torsemide (0.1 mg/kg PO q 12 h), furosemide (2.0 mg/kg PO q 12 h), or placebo for 10 days during three separate periods, separated by a 10-day washout period, in a crossover design. Blood was collected on days 1, 5, and 9 and 24-h urine collection ended on days 2, 6, and 10. After repeated measures analysis and Bonferonni correction, variables with an adjusted p<0.05 were investigated further, using Tukey's method.


Twenty-four-hour urine production differed significantly between the diuretics only on day 10, with torsemide causing a 38% greater diuresis than furosemide. There was, however, no significant difference in average 3-day diuresis. There were no significant differences between diuretics in the 24-h urinary excretion of sodium, chloride, or potassium, though furosemide caused less kaliuresis than torsemide. Serum renin, angiotensin II, and aldosterone and the urine aldosterone-to-creatinine ratio were significantly increased in the diuretic groups, as compared to placebo on days 5/6 and 9/10. There were no significant differences in these values between diuretics. Creatinine and blood urea nitrogen concentrations rose comparably in the diuretic groups, remaining within reference intervals in all dogs.


At approximately equipotent dosages (20:1), torsemide and furosemide produced comparable renin-angiotensin-aldosterone system activation. Torsemide's similar potassium excretion profile to furosemide decreases support for a hypothesized mineralocorticoid-receptor blocking capability.


Congestive heart failure; Diuretics; Kaliuresis; Urine aldosterone to creatinine ratio

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center