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J Asian Nat Prod Res. 2019 Dec 5:1-17. doi: 10.1080/10286020.2019.1694512. [Epub ahead of print]

Ameliorative effect of acetylshikonin on cigarette smoke-induced lung inflammation in mice.

Zhang XY1,2,3, Jia YP1,2,3, Zhao Q1,2,3, Wang WY1,2,3, Zhang Z4, Li W4, Sun LC4.

Author information

1
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
2
National Clinical Research Center for Respiratory Diseases, Beijing 100029, China.
3
Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing 100029, China.
4
Department of Emergency, China-Japan Friendship Hospital, Beijing 100029, China.

Abstract

Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD). Acetylshikonin was the active principle component of Purple Gromwell that show anti-oxidative and anti-inflammatory effect. However, no data are available to elucidate the protective effect of acetylshikonin on COPD. Acetylshikonin could attenuate smoke-induced lung pathological changes, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and monocyte chemoattractant protein 1 (MCP-1) productions, and tissue damages caused by oxidative stress. Furthermore, acetylshikonin was found to enhance the expression of Nrf2 and Nur77-mediated COX-2 in vivo and in vitro.

KEYWORDS:

Acetylshikonin; COPD; inflammation; oxidative stress; smoke inhalation

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