Format

Send to

Choose Destination
J Microsc Ultrastruct. 2019 Oct-Dec;7(4):198-200. doi: 10.4103/JMAU.JMAU_9_19. Epub 2019 Nov 18.

Increased Copy Number of Anaplastic Lymphoma Kinase Gene Signal in Lung Carcinomas: Is it Significant?

Author information

1
Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
2
Department of Biochemistry, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Abstract

The anaplastic lymphoma kinase gene re-arrangement which is present in 3-5% cases of non small cell lung cancer is a somatic gene re-arrangement. The gold standard for the identification of this gene re-arrangement is fluorescence in situ hybridization. Many variant hybridization patterns have been documented. We present a case of polysomy of ALK gene in the absence of ALK gene re-arrangement in a 45 year old female who presented with brain metastasis. This is a rare case of polysomy of ALK gene reported in a non small cell lung carcinoma. It may be indicative of a worse prognosis and may predict high metastatic potential in these tumors.

KEYWORDS:

Anaplastic lymphoma kinase; fluorescence in situ hybridization; polysomy

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center