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Heart Views. 2019 Oct-Dec;20(4):139-145. doi: 10.4103/HEARTVIEWS.HEARTVIEWS_21_19. Epub 2019 Nov 14.

Percutaneous Device Closure of Patent Ductus Arteriosus in Adult Patients with 10-Year Follow-up.

Alkashkari W1,2,3, Albugami S1,2,3, Alrahimi J1,2,3, Althobaiti M2,3,4, Kinsara A1,2,3, Abousa A1,2,3, Krimly A1,2,3, Alzahrani A1,2,3, Niazi A1,2,3, Aburemish H2,3,5.

Author information

1
Department of Cardiology, King Faisal Cardiac Center, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.
2
King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.
3
Department of Medical Research, King Saud Bin Abdulaziz University for Health Science, Jeddah, Saudi Arabia.
4
Department of Radiology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.
5
Department of Pediatric Cardiology, King Faisal Cardiac Center, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.

Abstract

Objectives:

We report our 10-year experience with transcatheter closure of patent ductus arteriosus (PDA) in adult using different closure devices.

Background:

Transcatheter closure of PDA in adults can be challenging because of frequently associated comorbidities. Reports on immediate and intermediate-term results of PDA closure are excellent. This study aimed to provide the outcomes of PDA closure using different devices on long and very long term follow-up in adults.

Materials and Methods:

Between September 2009 and December 2018, data were retrospectively reviewed from 27 patients who underwent transcatheter closure of PDA. Outcome parameters were procedural success, procedure-related complications, evidence of residual shunt, and improvement in the signs/symptoms for which the procedure was performed. The mean follow-up interval was 72 months.

Results:

A device was successfully implanted in 27 of 27 patients (15 females). Median age and weight were 24 years (range: 18-57 years) and 69 kg (range: 53-102 kg), respectively. The mean PDA diameter was 4.1 ± 2.1 mm. Devices used were Amplatzer Duct Occluder (19/27), Occlutech Duct Occluder (6/27), and PFM Nit-Occlud (2/27). Doppler transthoracic echocardiography (TTE) demonstrated 92.6% of full occlusion at day 1, rising to 96.3% at 1 month. Three procedure-related complications occurred with no death. Among symptomatic 26 patients (96.3%), there was marked improvement in symptoms. Among 22 patients (81.5%) for whom the procedure was performed to address left ventricular (LV) enlargement, there was reduction or stabilization in LV size on serial TTEs.

Conclusions:

Transcatheter closure of PDA in the adult patient appears to be safe and effective.

KEYWORDS:

Cardiac catheterization; heart failure; patent ductus arteriosus; pulmonary hypertension

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