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J Occup Environ Med. 2019 Dec;61 Suppl 12:S1-S4. doi: 10.1097/JOM.0000000000001752.

Use of Biomarkers to Assess Environmental Exposures and Health Outcomes in Deployed Troops.

Author information

1
Department of Preventive Medicine and Biostatistics, Uniformed Services University, Bethesda (Dr Mallon, Dr Krahl); Department of Environmental Medicine (Dr Woeller, Dr Hopke, Dr Utell); Pulmonary Division, Department of Medicine (Dr Thatcher, Dr Thakar, Dr Utell); Microbiology and Immunology (Dr Woeller); Department of Public Health Sciences (Dr Walker, Dr Smith, Dr Uppal, Dr Go, Dr Jones), Emory University, Atlanta, Georgia US Army Public Health Center, Edgewood (Dr Gaydos), Maryland; Medical Counter-CBRN and Environmental Health, Office of the Joint Staff Surgeon, The Pentagon, Washington DC (Mr Haines).

Abstract

OBJECTIVE:

This paper provides an overview of our Military Biomarkers Research Study (MBRS) designed to assess whether biomarkers can be used to retrospectively assess deployment exposures and health impacts related to deployment environmental exposures.

METHODS:

The MBRS consists of four phases. Phase I was a feasibility study of stored sera. Phase II looks at associations between exposures and biomarkers. Phase III examines relationships of biomarkers and health outcomes, and Phase IV investigates in vitro biomarker changes associated with exposures to chemicals of interest. This paper briefly summarizes work already published and introduces the new reports contained in this supplement.

RESULTS:

Novel biomarkers were identified. These were associated with deployment exposures.

CONCLUSIONS:

Significant associations were noted between deployment exposures, microRNA biomarkers and metabolomic biomarkers, and deployment health outcomes.

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