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Top Magn Reson Imaging. 2019 Dec;28(6):311-315. doi: 10.1097/RMR.0000000000000224.

Overview of MR Imaging Volumetric Quantification in Neurocognitive Disorders.

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Division of Neuroradiology, Department of Radiology, Mallinckrodt Institute of Radiology at Washington University, St. Louis, MO.
University of Pittsburgh Medical Scientist Training Program, Pittsburgh, PA.


This review article provides a general overview on the various methodologies for quantifying brain structure on magnetic resonance images of the human brain. This overview is followed by examples of applications in Alzheimer dementia and mild cognitive impairment. Other examples will include traumatic brain injury and other neurodegenerative dementias. Finally, an overview of general principles for protocol acquisition of magnetic resonance imaging for volumetric quantification will be discussed along with the current choices of FDA cleared algorithms for use in clinical practice.

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