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Int J Mycobacteriol. 2019 Oct-Dec;8(4):359-365. doi: 10.4103/ijmy.ijmy_142_19.

Determinants of treatment failure among tuberculosis patients in Kandahar City, Afghanistan: A 5-year retrospective cohort study.

Author information

1
Department of Paediatrics, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
2
Department of Histopathology, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
3
Department of Clinical Trials Support Group, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
4
Department of Surgery, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
5
Department of Internal Medicine, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.

Abstract

Background:

Tuberculosis (TB) is a preventable and treatable chronic disease. Afghanistan is among the high-TB-burden countries. The aim of this study is to find the determinants of treatment failure among TB patients in Kandahar City, Afghanistan.

Methods:

This was a retrospective cohort study conducted in Kandahar City during a period of 5 years (August 2014-July 2019). For data analysis; descriptive statistics, Chi-square test, and logistic regression were used.

Results:

Among 1416 TB patients, 894/1416 (63.1%) had pulmonary TB (PTB), whereas 522/1416 (36.9%) had extrapulmonary TB (EPTB). Mean age in these patients was 34.7 years while most of them were females in PTB (530/894 [59.3%]) and EPTB (340/522 [65.1%]) patients. Sputum smear was positive in 618/860 (71.9%) and 16/404 (4%) of PTB and EPTB patients, respectively. TB treatment failure was more in PTB (56/894 [6.3%]) than EPTB (4/522 [0.8%]). Chi-square test of TB cases showed that statistically significant determinants that may cause the treatment failure were re-treatment cases (crude odds ratio [COR] 7.7, P < 0.001), absence of fever (COR 5.2, P < 0.001), absence of cough (COR 1.7, P = 0.004), living in rural areas (COR 1.4, P = 0.035), and no weight loss (COR 1.3, P = 0.033). Binary logistic regression of the statistically significant variables revealed only absence of fever (adjusted odds ratio 6.0, P < 0.001) as the risk factor for treatment failure in TB patients.

Conclusion:

TB is still a major threat for Kandahar City. Low treatment success rate and increased number of defaulted cases are the major threats.

KEYWORDS:

Determinants; extrapulmonary; factors; pulmonary; tuberculosis

PMID:
31793506
DOI:
10.4103/ijmy.ijmy_142_19
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