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Int J Mycobacteriol. 2019 Oct-Dec;8(4):341-346. doi: 10.4103/ijmy.ijmy_158_19.

Effectiveness of anti-tuberculosis chemotherapy in patients with tuberculosis relapse compared with newly diagnosed patients.

Author information

1
Department of Phthisiology and Pulmonology, Kharkiv National Medical University, Kharkiv, Ukraine.
2
Department of Technologies of Treatment of Nonspecific Lung Diseases, SO National Institute of Phthisiology and Pulmonology Named after F.G. Yanovskyi NAMS of Ukraine, Kiev, Ukraine.
3
Department of Phthisiology and Pulmonology, National Medical Academy for Advanced Training Named after P.L. Shupik, Kiev, Ukraine.
4
Department of Biochemistry, Kharkiv National Medical University, Kharkiv, Ukraine.
5
Department of Criminalistics and Forensic Science, Kharkiv National University of Internal Affairs, Kharkiv, Ukraine.
6
Department of Internal Medicine, V.N. Karazin Kharkiv National University, Kharkiv, Ukraine.

Abstract

Background:

To study the effectiveness of antituberculosis chemotherapy in patients with relapse pulmonary tuberculosis (RTB) compared with patients with the newly diagnosed process.

Methods:

We examined 285 TB patients, including 126 individuals with RTB (Group 1) and 159 patients with newly diagnosed pulmonary tuberculosis (NDPTB) (Group 2). All patients were diagnosed with infiltrative PTB. Effectiveness of the basic course of antimycobacterial treatment was assessed in accordance with the following data: time required for the normalization of clinical manifestations, smear conversion, cavity healing, disappearance of infiltrative and focal changes in the pulmonary tissue, as well as the final clinical effectiveness of therapy.

Results:

Disappearance of clinical symptoms was statistically significantly faster in Group 2 compared with RTB patients in 2.25 ± 0.11 and 3.40 ± 0.15 months, respectively (P < 0.001). Sputum culture conversion was observed after 6 months of treatment in 138 (86.79%) patients with NDPTB and 89 (72.22%) patients from Group 1 (P = 0.0023). Closure of cavities and disappearance of infiltrative and focal changes in the lungs occurred within 6 months of chemotherapy only in 55 (43.65%) patients with RTB and 93 (58.49%) patients with NDPTB (P = 0.0133).

Conclusions:

Standard treatment for patients with NDPTB is considered successful in case of faster health improvement and stabilization, less pronounced rates of toxic adverse reactions to antiTB drugs, faster sputum smear and culture conversion and cavity healing, signs of clinical and radiological convalescence, and the reduced number of large residual changes after the treatment compared with RTB.

KEYWORDS:

Pulmonary tuberculosis relapse; treatment; tuberculosis; tuberculosis treatment effectiveness

PMID:
31793503
DOI:
10.4103/ijmy.ijmy_158_19
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