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Chin J Physiol. 2019 Nov-Dec;62(6):261-266. doi: 10.4103/CJP.CJP_52_19.

Sex Differences in antiaging response to short- and long-term high-intensity interval exercise in rat cardiac muscle: Telomerase activity, total antioxidant/oxidant status.

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Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran.
Department of Exercise Physiology, Islamic Azad University, Science and Research Branch, Tehran, Iran.
Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.


Cardiovascular disease prevails with age which varies according to sex. Telomere length plays an important role in aging. Despite the great benefits of high-intensity interval training (HIIT), the acute responses to HIIT with different intervals have not been elucidated in different sexes. This study was conducted to investigate the sex-dependent responses of telomerase enzyme activity, total oxidant status (TOS), total antioxidant capacity (TAC), and the ratio of TAC/TOS to short- and long-term high-intensity interval exercise (HIIE) in cardiac muscle of male and female rats. Forty adult Wistar rats were randomly allocated to six groups: male and female HIIE with short-term intervals (MHIIESh and FHIIESh, respectively), male and female HIIE with long-term intervals (MHIIEL and FHIIEL, respectively), and controls groups. Telomerase activity, TAC, and TOS levels were examined immediately after exercise in the cardiac muscle. The level of telomerase enzyme activity, TOS level, and the ratio of TAC/TOS did not change after HIIE with short-term interval and HIIE with long-term interval (HIIEL) in male and female rats (P = 0.52, 0.69, and 0.08, respectively). There was a statistically significant decrease in the TAC level in the MHIIESh group (P = 0.04). Furthermore, a significant decrease was observed in the HIIEL in both male and female rats (P = 0.03 and 0.04, respectively). Acute exposure to HIIE with short- and long-term intervals would not result in a significant change in some indicators of biological aging. However, due to gender-specific biological differences, further studies will provide evidence regarding the roles of HIIE at different times of intervals, which contribute to aging prevention.


Cardiac muscle; high-intensity interval exercise; sex differences; telomerase activity; total antioxidant/oxidant status

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