Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1988 Sep 30;155(3):1404-11.

Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro.

Author information

1
Rega Institute for Medical Research, Katholieke Universiteit, Leuven, Belgium.

Abstract

Fuchsin acid, an anionic dye, is a selective inhibitor of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) in vitro. Its 50% effective dose for inhibition of HIV-1-induced cytopathogenicity in MT-4 cells and HIV-1 antigen expression in HUT-78 cells is 42 and 16 microM, respectively. These values are comparable to those of suramin, the first compound shown to be a selective inhibitor of HIV-1. However, fuchsin acid is less cytotoxic than suramin. The selectivity index of fuchsin acid, based on the ratio of the 50% cytotoxic dose to the 50% effective dose, is greater than 74 in MT-4 cells and greater than 39 in HUT-78 cells. Fuchsin acid is a much weaker inhibitor of HIV-1 reverse transcriptase than are suramin and aurintricarboxylic acid. Fuchsin acid does not interfere with the adsorption of HIV-1 particles to MT-4 cells even at concentrations that completely block HIV-1 replication in MT-4 cells. The mechanism of action of fuchsin acid remains subject of further study.

PMID:
3178818
DOI:
10.1016/s0006-291x(88)81297-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center