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Pediatr Obes. 2019 Dec 1. doi: 10.1111/ijpo.12593. [Epub ahead of print]

Associations of nitric oxide with obesity and psychological traits among children and adolescents in Taiwan.

Author information

1
Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
2
Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
3
School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
4
School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.

Abstract

BACKGROUND:

Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant.

OBJECTIVE:

This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan.

METHODS:

A total of 564 first, fourth and seventh graders (314 children with overweight/obesity and 250 children with normal weight) completed an in-hospital health examination in 2010. All students received a physical examination, underwent blood sample collection and completed a questionnaire. Multiple linear regression analyses were performed for analyses.

RESULTS:

Among the fourth and seventh graders (P=.003 and.001, respectively), the students with overweight/obesity displayed significantly higher levels of NO than those with normal weight; however, no difference was observed in males and females. In multiple linear regression models, a high level of anxiety was independently associated with low NO levels (β=-1.33, 95% confidence interval -2.24 to -0.41) in first graders who with overweight/obesity. No association between NO levels and psychological traits was evident among students with normal weight.

CONCLUSIONS:

Our results enrich the limited data and suggest that NO may be associated with obesity and psychopathology and should be a concern in the pathophysiology of childhood mental health and obesity.

KEYWORDS:

anxiety; children; nitric oxide (NO); obesity

PMID:
31786830
DOI:
10.1111/ijpo.12593

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