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Stem Cell Res. 2019 Nov 13;42:101657. doi: 10.1016/j.scr.2019.101657. [Epub ahead of print]

Generation of eight human induced pluripotent stem cell lines from Parkinson's disease patients carrying familial mutations.

Author information

1
Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Denmark; Department of Biomedicine, Aarhus University, Denmark.
2
Department of Biomedicine, Aarhus University, Denmark; Department for Clinical Genetics, Aarhus University Hospital, Denmark.
3
Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Denmark; Department of Health Science and Technology, Aalborg University, Denmark.
4
Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, Aarhus University, Denmark; Department of Biomedicine, Aarhus University, Denmark. Electronic address: mden@dandrite.au.dk.

Abstract

We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease modeling to identify PD mechanisms and for the development or stratification of new drugs.

PMID:
31786474
DOI:
10.1016/j.scr.2019.101657
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