Format

Send to

Choose Destination
Neurochem Int. 2019 Nov 28:104615. doi: 10.1016/j.neuint.2019.104615. [Epub ahead of print]

Associations between long-term exposure to ambient air pollution and Parkinson's disease prevalence: A cross-sectional study.

Author information

1
University Centre for Rural Health - North Coast, School of Public Health, University of Sydney, Australia; Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia; Department of Epidemiology and Preventive Medicine, Monash University, Australia. Electronic address: farhad.salimi@sydney.edu.au.
2
University Centre for Rural Health - North Coast, School of Public Health, University of Sydney, Australia; Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia; Centre for Research and Action in Public Health, University of Canberra, Australia.
3
Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia; School of Public Health and Community Medicine and Ingham Institute for Applied Medical Research, University of New South Wales, Australia.
4
Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia; Centre for Research and Action in Public Health, University of Canberra, Australia.
5
University Centre for Rural Health - North Coast, School of Public Health, University of Sydney, Australia.
6
Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia; School of Population and Global Health, The University of Western Australia, Australia.
7
Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia; South West Sydney Clinical School, University of New South Wales, Sydney, Australia; Ingham Institute of Applied Medical Research, Liverpool, Australia; Woolcock Institute of Medical Research, University of Sydney, Australia.
8
Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia; School of Public Health, The University of Queensland, Australia.
9
CSIRO Oceans & Atmosphere, PMB1, Aspendale, VIC, Australia.
10
University Centre for Rural Health - North Coast, School of Public Health, University of Sydney, Australia; Centre for Air Pollution, Energy and Health Research and Evaluation (NHMRC Centre of Research Excellence), Australia.

Abstract

BACKGROUND:

Epidemiological studies have reported contradictory results regarding the effects of ambient air pollution on Parkinson's disease (PD). This study investigated the associations between long-term exposure to particulate matter <2.5 μm in diameter (PM2.5) and nitrogen dioxide (NO2) and PD among participants in the 45 and Up Study, which comprised adults older than 45 years living in New South Wales, Australia.

METHODS:

We conducted a cross-sectional analysis of long-term exposure to PM2.5 and NO2 concentrations and prevalence of PD using data from around 240,000 cohort members from the 45 and Up Study, NSW. Annual average concentrations of NO2 and PM2.5 were estimated at the participants' residential address using satellite-based land use regression models. Logistic regression was used to quantify the associations between these pollutants and ever physician-diagnosed PD, after adjusting for a range of individual- and area-level covariates.

RESULTS:

Among the 236,390 participants with complete data, 1,428 (0.6%) reported physician-diagnosed PD. Annual mean PM2.5 and NO2 concentrations for the cohort were 5.8 and 11.9 μg m-3, respectively, and were positively, but not statistically significantly associated with PD. The odds ratio for a 1 μg m-3 increase in PM2.5 was 1.01 (95% confidence interval (CI): 0.98-1.04). The adjusted odds ratio for a 5 μg m-3 increase in NO2 was 1.03 (95% CI: 0.98-1.08). In subgroup analyses, larger associations for NO2 were observed among past smokers (OR 1.11 (95% CI: 1.02-1.20) per 5 μg m-3 increase).

CONCLUSIONS:

Overall, we found limited evidence of associations between long-term exposure to NO2 or PM2.5 and PD. The associations observed among past smokers require further corroboration.

KEYWORDS:

45 and up study; Air pollution; Parkinson's disease; Particulate matter

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center