Format

Send to

Choose Destination
Curr Biol. 2019 Dec 16;29(24):4218-4230.e8. doi: 10.1016/j.cub.2019.10.042. Epub 2019 Nov 27.

Serotonergic Modulation of Walking in Drosophila.

Author information

1
Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Medical Scientist Training Program, Columbia University, New York, NY 10027, USA.
2
Brain Mind Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland; Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
3
Advanced Instrumentation Group, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.
4
Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Departments of Biochemistry and Molecular Biophysics and Neuroscience, Columbia University, New York, NY 10027, USA. Electronic address: rsm10@columbia.edu.

Abstract

To navigate complex environments, animals must generate highly robust, yet flexible, locomotor behaviors. For example, walking speed must be tailored to the needs of a particular environment. Not only must animals choose the correct speed and gait, they must also adapt to changing conditions and quickly respond to sudden and surprising new stimuli. Neuromodulators, particularly the small biogenic amine neurotransmitters, have the ability to rapidly alter the functional outputs of motor circuits. Here, we show that the serotonergic system in the vinegar fly, Drosophila melanogaster, can modulate walking speed in a variety of contexts and also change how flies respond to sudden changes in the environment. These multifaceted roles of serotonin in locomotion are differentially mediated by a family of serotonergic receptors with distinct activities and expression patterns.

KEYWORDS:

5-HT; 5-HT receptors; Drosophila; locomotion; neuromodulation; serotonin; startle response; walking; walking gaits

PMID:
31786064
PMCID:
PMC6935052
[Available on 2020-12-16]
DOI:
10.1016/j.cub.2019.10.042

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center