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Stem Cell Res. 2019 Nov 21;41:101664. doi: 10.1016/j.scr.2019.101664. [Epub ahead of print]

Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi003-A) from a Wilson's disease patient harboring a homozygous R778L mutation in ATP7B gene.

Author information

1
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450052, China. Electronic address: jiweizhang26@gmail.com.
2
Department of Neurology, Luoyang Central Hospital affiliated to Zhengzhou University, Luoyang, Henan 467500, China.
3
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
4
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangzhou 510530, China.
5
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. Electronic address: lixunhua26@163.com.

Abstract

Human IPSC Line, ZZUNEUi003-A, was generated from a 32-year-old male patient with Wilson's Disease carrying a homozygous R778L mutation in ATP7B gene, using non-integrative reprogramming method. This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype.

PMID:
31783295
DOI:
10.1016/j.scr.2019.101664
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