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Parasite. 2019;26:70. doi: 10.1051/parasite/2019070. Epub 2019 Nov 29.

Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities.

Author information

1
Immunology Research Center, Tabriz University of Medical Sciences, 5166/15731 Tabriz, Iran - Student Research Committee, Tabriz University of Medical Sciences, 5166/15731 Tabriz, Iran.
2
Malaria Research Unit, SMITh, ICBMS, UMR 5246 CNRS INSA CPE University Lyon, 69100 Lyon, France - Institute of Parasitology and Medical Mycology, Croix-Rousse Hospital, Hospices Civils de Lyon, 69004 Lyon, France.
3
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, 5166/15731 Tabriz, Iran - Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences, 5166/15731 Tabriz, Iran.

Abstract

in English, French

Cystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. Immune response modulation and regulated cell death (RCD) play a fundamental role in cyst formation, development and pathogenesis. RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. In this review, we provide a general overview of current knowledge on the process of RCD during echinococcosis. The study of interactions between RCD and Echinococcus spp. metacestodes may provide in-depth understanding of echinococcosis pathogenesis and open new horizons for human intervention and treatment of the disease.

KEYWORDS:

Apoptosis; Autophagy; Echinococcosis; Hydatid cyst; Necrosis; Regulated cell death

PMID:
31782727
DOI:
10.1051/parasite/2019070
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