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Curr Mol Med. 2019 Nov 28. doi: 10.2174/1566524019666191129104153. [Epub ahead of print]

Short-term Effect of Fresh Pomegranate Juice on Serum Cortisol and Thyroxine in Patients with type 2 Diabetes

Author information

1
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan.
2
Department of Physiology and Biochemistry, Jordan University of Science and Technology, Irbid 22110, Jordan.

Abstract

BACKGROUND:

The effect of pomegranate juice on type 2 diabetic conditions has been determined in various occasions. However, such an effect on cortisol and thyroxine hormones, which are major controllers of energy metabolism, is not yet revealed.

OBJECTIVES:

In this study, we intended to measure the short-term effect of fresh pomegranate juice on serum cortisol and thyroxine in patients with type 2 diabetes.

MATERIALS AND METHODS:

This study was a randomized clinical trial in which 89 fasted patients with type 2 diabetes were supplemented with fresh pomegranate juice at a dose of 1.5 mL kg-1. Blood specimens were then collected before and at 1 and 3 hours after juice administration. Serum cortisol and thyroxine were assessed using commercial chemiluminescent-immunoassay kits.

RESULTS:

Serum cortisol, but not thyroxine, was significantly (P < 0.0001) lower in patients with type 2 diabetes after ingesting fresh pomegranate juice. In addition, no significant correlation (r2 = 0.00003, P = 0.9569) was observed between cortisol response to fresh pomegranate juice and the level of fasting serum glucose in the recruited patients. Moreover, no significant difference (P = 0.9118) in cortisol response to fresh pomegranate juice was found between recruited males and females.

CONCLUSIONS:

In conclusion, fresh pomegranate juice decreased serum cortisol, 1 hour after juice ingestion, but not serum thyroxine 3 hours after juice ingestion, in patients with type 2 diabetes. In addition, cortisol response to fresh pomegranate juice was found not to be affected by patients’ gender and the level of fasting serum glucose.

KEYWORDS:

Cortisol; Pomegranate juice; Thyroxine; Type 2 diabetes

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