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Curr Pharm Des. 2019;25(42):4536-4549. doi: 10.2174/1381612825666191127114054.

Exosomes and Bone Disease.

Author information

1
Department of Endocrinology and Metabolism, National Clinical Research Center for Metabolic Diseases, Hunan Provincial Key Laboratory for Metabolic Bone Disease, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China.
2
Department of Pathology, The Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China.

Abstract

Exosomes, which mediate cell-to-cell communications and provide a novel insight into information exchange, have drawn increasing attention in recent years. The homeostasis of bone metabolism is critical for bone health. The most common bone diseases such as osteoporosis, osteoarthritis and bone fractures have apparent correlations with exosomes. Accumulating evidence has suggested the potential regenerative capacities of stem cell-derived exosomes. In this review, we summarise the pathophysiological mechanism, clinical picture and therapeutic effects of exosomes in bone metabolism. We introduce the advantages and challenges in the application of exosomes. Although the exact mechanisms remain unclear, miRNAs seem to play major roles in the exosome.

KEYWORDS:

Exosomes; fracture healing; microRNAs; osteoarthritis; osteoporosis; regeneration.

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