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Fundam Clin Pharmacol. 2019 Nov 27. doi: 10.1111/fcp.12524. [Epub ahead of print]

The curative effect of a cannabinoid 2 receptor agonist on functional failure and disruptive inflammation caused by intestinal ischemia and reperfusion.

Author information

1
Department of Pharmacology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
2
Department of Anesthesia, Pain Management & Perioperative Medicine, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
3
Department of Microbiology & Immunology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.

Abstract

As we learn more about the endocannabinoid system (ECS), our understanding and grasp of the system's ubiquitous presence is expanding. In light of this, there is also a growing body of evidence for the therapeutic potential of ECS modulation in a range of clinical situations. Strategies include for example manipulation of the Cannabinoid 1 (CB1) receptor, mostly in terms of CNS processes, and activation of the Cannabinoid 2 (CB2) receptor as anti-inflammatory target.

PMID:
31774568
DOI:
10.1111/fcp.12524

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