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Magn Reson Med. 2019 Nov 27. doi: 10.1002/mrm.28095. [Epub ahead of print]

Real-time MR elastography for viscoelasticity quantification in skeletal muscle during dynamic exercises.

Author information

1
Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
2
Institute of Medical Informatics, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Abstract

PURPOSE:

To develop and test real-time MR elastography for viscoelastic parameter quantification in skeletal muscle during dynamic exercises.

METHODS:

In 15 healthy participants, 6 groups of lower-leg muscles (tibialis anterior, tibialis posterior, peroneus, extensor digitorum longus, soleus, gastrocnemius) were investigated by real-time MR elastography using a single-shot, steady-state spiral gradient-echo pulse sequence and stroboscopic undersampling of harmonic vibrations at 40 Hz frequency. One hundred and eighty consecutive maps of shear-wave speed and loss angle (φ) covering 30.6 s of total acquisition time at 5.9-Hz frame rate were reconstructed from 360 wave images encoding 2 in-plane wave components in an interleaved manner. The experiment was carried out twice to investigate 2 exercises-isometric plantar flexion and isometric dorsiflexion-each performed over 10 s between 2 resting periods.

RESULTS:

Activation of lower-extremity muscles was associated with increasing viscoelastic parameters shear-wave speed and φ, both reflecting properties related to the transverse direction relative to fiber orientation. Major viscoelastic changes were observed in soleus muscle during plantar flexion (shear-wave speed: 20.0% ± 3.6%, φ: 41.3% ± 12.0%) and in the tibialis anterior muscle during dorsiflexion (41.8% ± 10.2%, φ: 27.9% ± 2.8%; all P < .0001). Two of the muscles analyzed were significantly activated by plantar flexion and 4 by dorsiflexion based on shear-wave speed, whereas φ changed significantly in 5 muscles during both exercises.

CONCLUSION:

Real-time MR elastography allows mapping of dynamic, nonperiodic viscoelasticity changes in soft tissues such as voluntary muscle with high spatial and temporal resolution. Real-time MR elastography thus opens new horizons for the in vivo study of physiological processes in soft tissues toward functional elastography.

KEYWORDS:

activity patterns; dynamic exercise; real-time MRE; skeletal muscle function; stiffness; viscoelasticity

PMID:
31774210
DOI:
10.1002/mrm.28095

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