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Hum Genet. 2019 Nov 26. doi: 10.1007/s00439-019-02092-8. [Epub ahead of print]

Mx genes: host determinants controlling influenza virus infection and trans-species transmission.

Haller O1,2,3, Kochs G4,5.

Author information

1
Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany. otto.haller@uniklinik-freiburg.de.
2
Faculty of Medicine, University of Freiburg, Freiburg, Germany. otto.haller@uniklinik-freiburg.de.
3
Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. otto.haller@uniklinik-freiburg.de.
4
Institute of Virology, Medical Center, University of Freiburg, Freiburg, Germany.
5
Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Abstract

The human MxA protein, encoded by the interferon-inducible MX1 gene, is an intracellular influenza A virus (IAV) restriction factor. It can protect transgenic mice from severe IAV-induced disease, indicating a key role of human MxA for host survival and suggesting that natural variations in MX1 may account for inter-individual differences in disease severity among humans. MxA also provides a robust barrier against zoonotic transmissions of avian and swine IAV strains. Therefore, zoonotic IAV must acquire MxA escape mutations to achieve sustained human-to-human transmission. Here, we discuss recent progress in the field.

PMID:
31773252
DOI:
10.1007/s00439-019-02092-8

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