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J Immunol Res. 2019 Oct 27;2019:7546047. doi: 10.1155/2019/7546047. eCollection 2019.

The Dynamic Interplay between the Gut Microbiota and Autoimmune Diseases.

Xu H#1, Liu M#1, Cao J1, Li X2,3, Fan D2,3, Xia Y2, Lu X2, Li J4, Ju D1, Zhao H1.

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Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Science, Beijing 100700, China.
Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China.
Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100193, China.
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.
Contributed equally


The human gut-resident commensal microbiota is a unique ecosystem associated with various bodily functions, especially immunity. Gut microbiota dysbiosis plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases. However, the role of the gut microbiota, which causes or influences systemic immunity in autoimmune diseases, remains elusive. Aryl hydrocarbon receptor, a ligand-activated transcription factor, is a master moderator of host-microbiota interactions because it shapes the immune system and impacts host metabolism. In addition, treatment optimization while minimizing potential adverse effects in autoimmune diseases remains essential, and modulation of the gut microbiota constitutes a potential clinical therapy. Here, we present evidence linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development to identify future effective approaches based on the gut microbiota for preventing autoimmune diseases.

Conflict of interest statement

The authors declare that there is no conflict of interest.

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