Pediatric mediastinal ALK- negative anaplastic large cell lymphoma (Hodgkin-like pattern) in a 13-year-old girl: a case report and review of literature

Sawsan Ismail; Mariana Haydar; Abdulmoniem Ghanem; Sulman Alkadi; Zuheir Al-Shehabi

doi:10.1093/omcr/omz077

Pediatric mediastinal ALK- negative anaplastic large cell lymphoma (Hodgkin-like pattern) in a 13-year-old girl: a case report and review of literature

Oxf Med Case Reports. 2019 Aug 28;2019(8):omz077. doi: 10.1093/omcr/omz077. eCollection 2019 Aug.

Authors

Sawsan Ismail¹, Mariana Haydar², Abdulmoniem Ghanem³, Sulman Alkadi⁴, Zuheir Al-Shehabi¹

Affiliations

¹ Department of Pathology, Faculty of Medicine, Tishreen University, Lattakia, Syria.
² Department of Pediatrics, Pediatrics and Obstetrics Hospital, Lattakia, Syria.
³ Department of Pediatrics, Faculty of Medicine, Tishreen University, Lattakia, Syria.
⁴ Department of Thoracic Surgery, Faculty of Medicine, Tishreen University, Lattakia, Syria.

Abstract

Anaplastic large-cell Lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma that is characterized by an entity of large neoplastic cells labeled by the Ki-1 antibody. It constitutes ~2% of all lymphoid neoplasms and is divided into two main categories: anaplastic large-cell kinase (ALK)+ALCL and ALK-ALCL that is recognized by the absence of ALK expression and mostly affects men at older ages. Thus, in this report we present a rare case of ALK-negative ALCL (ALK-ALCL) that was described and diagnosed in a 13-year-old girl in the mediastinum. Highlighting the rarity of manifestation at younger ages and the importance of using immunohistochemical staining in the differential diagnosis of this lymphoid neoplasm.

Publication types

Case Reports