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J Orthop Res. 2019 Nov 26. doi: 10.1002/jor.24538. [Epub ahead of print]

"Pulsed electromagnetic field modulates tendon cells response in IL-1β conditioned environment".

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3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal.
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, 4805-017 Barco, Guimarães, Portugal.


Strategies aiming at controlling and modulating inflammatory cues may offer therapeutic solutions for improving tendon regeneration. This study aims to investigate the modulatory effect of pulsed electromagnetic field (PEMF) on the inflammatory profile of human tendon-derived cells (hTDCs) after supplementation with IL-1β. IL-1β was used to artificially induce inflammatory cues associated to injured tendon environments. The PEMF effect was investigated varying the frequency (5 or 17 Hz), intensity (1.5, 4 or 5mT) and duty cycle (10 or 50%) parameters to which IL-1β treated hTDCs were exposed to. A PEMF actuation with 4mT, 5Hz and a 50% duty cycle decreased the production of IL-6 and TNFα as well as the expression of TNFα, IL-6, IL-8, COX-2, MMP-1, MMP-2 and MMP-3, while IL-4, IL-10 and TIMP-1 expression increased. These results suggest that PEMF stimulation can modulate hTDCs response in an inflammatory environment holding therapeutic potential for tendon regenerative strategies. This article is protected by copyright. All rights reserved.


IL-1β; cytokines; human tendon derived cells; inflammation; pulsed electromagnetic field


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