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FEBS Lett. 2019 Nov 26. doi: 10.1002/1873-3468.13697. [Epub ahead of print]

Epigenetics and the dynamics of chromatin during adenovirus infections.

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Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Department of Biology, Georgia State University, Atlanta, GA.
Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC.


The DNA genome of eukaryotic cells is compacted by histone proteins within the nucleus to form chromatin. Nuclear-replicating viruses such as adenovirus have evolved mechanisms of chromatin manipulation to promote infection and subvert host defenses. Epigenetic factors may also regulate persistent adenovirus infection and reactivation in lymphoid tissues. In this review we discuss the viral proteins E1A and protein VII that interact with and alter host chromatin, as well as E4orf3, which separates host chromatin from sites of viral replication. We also highlight recent advances in chromatin technologies that offer new insights into virus-directed chromatin manipulation. Beyond the role of chromatin in the viral replication cycle, we discuss the nature of persistent viral genomes in lymphoid tissue and cell lines, and the potential contribution of epigenetic signals in maintaining adenovirus in a quiescent state. By understanding the mechanisms through which adenovirus manipulates host chromatin, we will understand new aspects of this ubiquitous virus and shed light on previously unknown aspects of chromatin biology.


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