Sinonasal Mucormycosis: A to Z

Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 3):1962-1971. doi: 10.1007/s12070-018-1384-6. Epub 2018 May 4.

Abstract

Mucormycosis caused by one of the members of Mucoraceae family, is one of the most rapidly spreading and fatal fungal infection occurring mostly in Diabetic or Immunocompromised patients especially in developing countries. 26 patients suffering from sinonasal mucormycosis admitted in SGRRIM&HS, Dehradun from January 2013 to January 2017 are discussed. Diagnosis of mucormycosis was established on strong clinical suspicion with presence of grayish black crusting on nasal endoscopy which is confirmed by histopathology examination. Immediate correction of underlying immunocompromised status with debridement with intravenous liposomal amphotericin B was done in all the 26 cases out of which 10 patients were cured. Early detection and aggressive multidisciplinary management is must for the successful treatment of mucormycosis.

Keywords: Amphotericin; Invasive fungal sinusitis; Rhinocerebral mucormycosis; Rhizopus oryzae.