RNA-Binding Proteins Chaperone Ribonucleoprotein Complex Assembly to Solve the RNA-Folding Problem

Cell. 2019 Nov 27;179(6):1248-1250. doi: 10.1016/j.cell.2019.11.011. Epub 2019 Nov 21.

Abstract

The inherent tendency of RNAs to misfold is a major problem that can impede efficient assembly of essential ribonucleoprotein complexes (RNPs), such as ribosomes. In this issue of Cell, Duss et al., (2019) and Rodgers and Woodson (2019) reveal how transient RNA-protein interactions can chaperone RNA folding during RNP assembly.

Publication types

  • Comment

MeSH terms

  • RNA Folding*
  • RNA*
  • RNA, Ribosomal
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • Ribosomes

Substances

  • RNA, Ribosomal
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • RNA