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Stem Cell Res. 2019 Nov 15;41:101661. doi: 10.1016/j.scr.2019.101661. [Epub ahead of print]

Establishment of induced pluripotent stem cell line (GSPHi001-A) from a 6-year old female with nephrotic syndrome.

Author information

1
Nephrology department, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China; Pediatric department, Gansu provincial Hospital, Lanzhou 730000, China. Electronic address: xiagao@tom.com.
2
Intensive care unit, Gansu provincial Hospital, Lanzhou 730000, China.
3
Pediatric department, Gansu provincial Hospital, Lanzhou 730000, China.
4
Nephrology department, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

Abstract

Peripheral blood mononuclear cells (PBMCs) were collected from a 6-year-old female child who was clinically diagnosed as primary nephrotic syndrome (NS) with hormone resistance. An iPSC line was successfully established by the Sendai-virus (SeV) delivery system. The iPS-19 (GSPHi001-A) expressed pluripotent markers, exhibited a normal karyotype and differentiated towards three germ layers. The iPSC line might offer a potentially useful tool for investigating mechanisms of primary NS, drug testing and gene therapy studies.

PMID:
31759290
DOI:
10.1016/j.scr.2019.101661
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