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Diabetes. 2020 Feb;69(2):259-266. doi: 10.2337/db19-0606. Epub 2019 Nov 22.

Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank.

Author information

1
Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
2
The Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA.
3
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
4
Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO.
5
Genetics of Complex Traits, University of Exeter Medical School, Exeter, U.K.
6
Division of Endocrinology, Diabetes and Gastroenterology, Faculty of Biology, Medicine and Health, School of Medical Sciences, University of Manchester, Manchester, U.K.
7
Manchester Diabetes Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K.
8
Department of Physiology, University of Murcia, Murcia, Spain.
9
Biomedical Research of Murcia (IMIB-Arrixaca), Murcia, Spain.
10
Division of Sleep Medicine, Harvard Medical School, Boston, MA.
11
Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA.
12
Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA rsaxena@mgh.harvard.edu.

Abstract

Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint interaction effects of these risk factors on odds of type 2 diabetes (n = 5,042 cases) and HbA1c levels (n = 175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk allele associated with type 2 diabetes and HbA1c levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between self-reported morningness-eveningness preference and rs10830963 on risk of type 2 diabetes was seen, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when accelerometer-derived sleep midpoint was used as an objective measure of morningness-eveningness preference. Our findings suggest that MTNR1B risk allele carriers who carry out shift work or have more extreme morningness-eveningness preference may not have enhanced risk of type 2 diabetes.

PMID:
31757795
PMCID:
PMC6971490
[Available on 2021-02-01]
DOI:
10.2337/db19-0606

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