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Antioxidants (Basel). 2019 Nov 20;8(12). pii: E571. doi: 10.3390/antiox8120571.

Andrographolide, a Natural Antioxidant: An Update.

Author information

1
Laboratory I3MTO, EA 4708, Université d'Orléans, 45067 Orléans Cedex 2, France.
2
Service de Rhumatologie, Centre Hospitalier Régional d'Orléans 14 Avenue de l'Hôpital, 45100 Orléans, France.
3
Plateforme Recherche Innovation Médicale Mutualisée d'Orléans, Centre Hospitalier Régional d'Orléans CHRO, 41220 St Laurent Nouan, France.
4
NOVAXIA-6 Rue des champs Godin, 41220 St Laurent Nouan, France.
5
Institut de Chimie Organique et Analytique, Université d'Orléans-Pôle de Chimie, UMR CNRS 7311, Rue de Chartres, 45067 Orléans, France.

Abstract

Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This manuscript is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.

KEYWORDS:

Andrographis paniculata; Nrf2; andrographolide; oxidative stress

PMID:
31756965
DOI:
10.3390/antiox8120571
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