Format

Send to

Choose Destination
Indian J Ophthalmol. 2019 Dec;67(12):1974-1980. doi: 10.4103/ijo.IJO_59_19.

To compare intralesional and oral propranolol for treating periorbital and eyelid capillary hemangiomas.

Author information

1
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi; Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
2
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
3
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi; Department of Ophthalmology, Grewal Eye Institute, Chandigarh, India.
4
Department of Ophthalmology, Grewal Eye Institute, Chandigarh, India.
5
Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Purpose:

A pilot randomized control trial to compare the efficacy and side effects of intralesional and oral propranolol in periorbital and eyelid capillary hemangiomas.

Methods:

Twenty patients were prospectively randomized to two groups of ten each. Group 1 was initiated on oral propranolol 1 mg/kg/day titrated to final dose of 3 mg/kg/day over 1 week which was continued for 6 months and then tapered over 1 week; Group 2 received 3 doses of direct intralesional propranolol hydrochloride 1 mg/ml; 0.2 ml/cm 4-6 weeks apart. Hemangioma area and corneal astigmatism were measured.

Results:

Within each group at 6 months there was a significant reduction in area (group 1: 83.48 ± 11.67%,P= 0.0019; group 2: 67.78 ± 21.71%,P= 0.0019) and improvement in astigmatism (pre, post: group 1: 2.98D @ 179.8°, 1.13D @ 179.8°,P= 0.0045; group 2: 1.62D @ 90.16°, 0.75D @ 179.9°,P= 0.0001). There was no difference in area reduction (P = 0.056), change in appearance (P = 0.085), ptosis (P = 0.23) and side effects (lethargy, poor feeding;P= 0.171) between the two groups.

Conclusion:

Efficacy and side effects with intralesional propranolol are comparable to oral propranolol for periorbital and eyelid lesions.

KEYWORDS:

Capillary hemangioma; intralesional propranolol; oral propranolol

PMID:
31755431
DOI:
10.4103/ijo.IJO_59_19
Free full text

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd
Loading ...
Support Center