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Curr Drug Metab. 2019 Nov 21. doi: 10.2174/1389200220666191122104955. [Epub ahead of print]

A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy.

Author information

1
Stem Cell Laboratory, Institute of Endocrinology and Oncology, Naples. Italy.
2
Reproductive Biotechnology Centre, Dubai. United Arab Emirates.
3
Department of Zoology, Visvodaya Government Degree College, Venkatagiri. India.
4
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta GA-30322. United States.
5
Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur. India.
6
Department of Biotechnology and Bioinformatics, Sambalpur University, Sambalpur. India.

Abstract

BACKGROUND:

The introduction of Monoclonal Antibodies (mAbs) and small molecule Tyrosine Kinase Inhibitors (TKIs) that target the Epidermal Growth Factor Receptor (EGFR), mark a huge step forward in the Pancreatic Cancer (PC) therapy. However, anti-EGFR therapy found to be successful only in a fraction of patients. Although anti-EGFR agents have shown considerable clinical promise, serious adverse event associated with anti-EGFR therapy has been the challenging. At this juncture, there is still more to be done in the search for effective predictive markers with therapeutic applicability.

METHODS:

A focused literature search was conducted to summarize the existing evidences on anti-EGFR agents in pancreatic cancer therapy.

RESULTS:

This review discusses the various anti-EGFR agents currently in use for PC therapy and potential adverse effects associated with it. Existing evidences on EGFR TKIs demonstrated better tolerant effects and outcomes with multiple toxic regimens. Anti-EGFR therapy in combination with chemotherapy is necessary to achieve best clinical outcomes.

CONCLUSION:

Future prospective studies on identification of additional biological agents and novel anti-EGFR agents are warranted.

KEYWORDS:

Anti-EGFR Agents; Chemotherapy; EGFR; Pancreatic Cancer; Therapy; Toxicity

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