Format

Send to

Choose Destination
Neuron. 2020 Jan 8;105(1):165-179.e8. doi: 10.1016/j.neuron.2019.09.045. Epub 2019 Nov 18.

Excitatory and Inhibitory Subnetworks Are Equally Selective during Decision-Making and Emerge Simultaneously during Learning.

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
2
Neuroscience, Columbia University, New York, NY 10027, USA.
3
Gatsby Computational Neuroscience Unit, University College London, London, UK.
4
Flatiron Institute, New York, NY, USA.
5
Statistics, Columbia University, New York, NY 10010, USA.
6
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: achurchl@cshl.edu.

Abstract

Inhibitory neurons, which play a critical role in decision-making models, are often simplified as a single pool of non-selective neurons lacking connection specificity. This assumption is supported by observations in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific connectivity in slice. The selectivity of excitatory and inhibitory neurons within decision circuits and, hence, the validity of decision-making models are unknown. We simultaneously measured excitatory and inhibitory neurons in the posterior parietal cortex of mice judging multisensory stimuli. Surprisingly, excitatory and inhibitory neurons were equally selective for the animal's choice, both at the single-cell and population level. Further, both cell types exhibited similar changes in selectivity and temporal dynamics during learning, paralleling behavioral improvements. These observations, combined with modeling, argue against circuit architectures assuming non-selective inhibitory neurons. Instead, they argue for selective subnetworks of inhibitory and excitatory neurons that are shaped by experience to support expert decision-making.

PMID:
31753580
PMCID:
PMC6952547
[Available on 2021-01-08]
DOI:
10.1016/j.neuron.2019.09.045

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center