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Comput Biol Chem. 2019 Dec;83:107148. doi: 10.1016/j.compbiolchem.2019.107148. Epub 2019 Nov 10.

Recent advances in computational modeling of fibrin clot formation: A review.

Author information

1
School of Chemical, Materials and Biomedical Engineering, University of Georgia, 597 D.W. Brooks Drive, Athens, GA 30602.
2
School of Chemical, Materials and Biomedical Engineering, University of Georgia, 597 D.W. Brooks Drive, Athens, GA 30602. Electronic address: raverett@uga.edu.

Abstract

The field of thrombosis and hemostasis is crucial for understanding and developing new therapies for pathologies such as deep vein thrombosis, diabetes related strokes, pulmonary embolisms, and hemorrhaging related diseases. In the last two decades, an exponential growth in studies related to fibrin clot formation using computational tools has been observed. Despite this growth, the complete mechanism behind thrombus formation and hemostasis has been long and rife with obstacles; however, significant progress has been made in the present century. The computational models and methods used in this context are diversified into different spatiotemporal scales, yet there is no single model which can predict both physiological and mechanical properties of fibrin clots. In this review, we list the major strategies employed by researchers in modeling fibrin clot formation using recent and existing computational techniques. This review organizes the computational strategies into continuum level, system level, discrete particle (DPD), and multi-scale methods. We also discuss strengths and weaknesses of various methods and future directions in which computational modeling of fibrin clots can advance.

KEYWORDS:

Fibrin clot modeling; Hemostasis; Mechanics; Multiscale modeling; Thrombosis

PMID:
31751883
PMCID:
PMC6918949
[Available on 2020-12-01]
DOI:
10.1016/j.compbiolchem.2019.107148
[Indexed for MEDLINE]

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