Send to

Choose Destination
J Lasers Med Sci. 2019 Summer;10(3):189-193. doi: 10.15171/jlms.2019.30. Epub 2019 Jul 6.

Comparison and Evaluation of the Low-Level Laser and the Red and Blue LED Effects on Wound Healing in Rabbit.

Author information

Yas Hospital, Tehran University of Medical Science, Tehran, Iran.
Department of Surgery and Radiology, Faculty of Veterinary Medicine, the University of Tehran, Tehran, Iran.
Canadian Laser Training Institute (CLTI), Victoria, Canada.
Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Department of Veterinary Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Internal Medicine, Lenox Hill Hospital, New York, USA.


Introduction: Wound healing is a dynamic, interactive process to achieve the restoration of skin integrity and proper function after damage. Applying a low-level laser (LLL) and light emitting diodes (henceforth LEDs) is introduced in previous studies to accelerate the process of wound healing. The aim of this study is to compare the effect of the LLL and LEDs on wound healing in rabbits. Methods: Full thickness same size square excision wounds were created on the dorsum of the rabbits. Twenty rabbits were randomly divided into four groups, according to the treatment received. Group 1: the AlGalInP (aluminium gallium indium phosphide) laser (4 J/cm²); group 2: the red LED (30 J/cm²); group 3: the blue LED (60 J/cm²) and group 4, as the control group, was not irradiated. After 30 days, the wounds were evaluated both morphologically and histopathologically. Statistical significance was defined as a P value of less than 0.05. Results: All interfering methods including the LLL and LEDs had better outcome compared with the control group of both sizes and histopathologic features. The red laser group showed better results compared to the control group and either the LED groups. Comparing LEDs, the red LED performed better than the blue LED. Conclusion: This study confirmed the significant effects of the LLL and LEDs on wound healing. Comparing the LLL and LED, the LED may be a better choice, especially for bedridden or debilitated patients. The LED may also more cost effective in wound healing in comparison with the LLL.


Light emitting diode; Low-level laser; Wound healing

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center