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J Child Psychol Psychiatry. 2019 Nov 20. doi: 10.1111/jcpp.13153. [Epub ahead of print]

Neurocognitive risk markers in pediatric obsessive-compulsive disorder.

Author information

1
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
2
Provincial OCD Program, British Columbia Children's Hospital, Vancouver, BC, Canada.
3
Department of Education and Counselling Psychology and Special Education, University of British Columbia, Vancouver, BC, Canada.

Abstract

BACKGROUND:

Obsessive-compulsive disorder (OCD) has complex genetic underpinnings, particularly in its early-onset form, which places siblings at a 10-fold increased risk of developing the disorder. Examination for neurocognitive markers preceding pediatric OCD onset has not been conducted, although markers have been identified in adult OCD. This study compared neurocognition across groups of OCD-affected youth (n = 87), unaffected siblings of those with early-onset OCD (n = 67), and healthy controls (HC; n = 79).

METHODS:

A total of 233 participants aged 6-18 years old completed standardized neurocognitive tests of cognitive flexibility, decision making, planning, response inhibition, spatial working memory, attention, recognition nonverbal memory, and intelligence. They were administered the Anxiety Disorders Interview Schedule-Parent version (ADIS-P) and completed self-report anxiety and OCD questionnaires. Linear mixed-effects models tested for differences between groups, adjusting for age, gender, IQ, state anxiety, and ethnicity, and accounting for random effects of family membership.

RESULTS:

OCD-affected youth and unaffected siblings performed significantly worse on planning in comparison to HCs (Cohen's d = 0.74; 95% CI = [0.11, 1.36]; Cohen's d = 0.75; 95% CI = [0.12, 1.38], respectively; omnibus group effect p = .007). No other significant between-group differences were identified.

CONCLUSIONS:

Neurocognitive performance differences between groups identified planning as a preexisting trait marker of pediatric OCD, while no other domain presented as a marker of pediatric OCD. This differs from adult OCD, which is associated with broader cognitive impairments. Investigating longitudinal trajectories and predictive significance of neurocognition in those affected by, and at risk for, early-onset OCD is warranted. Ideally, this will enhance individualized risk stratification and inform future prevention and early intervention strategies.

KEYWORDS:

Cognitive; Obsessive-compulsive disorder; biomarker; genetics; pediatrics

PMID:
31749150
DOI:
10.1111/jcpp.13153

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