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BMC Musculoskelet Disord. 2019 Nov 20;20(1):556. doi: 10.1186/s12891-019-2851-2.

Bone mesenchymal stem cell therapy for ovariectomized osteoporotic rats: a systematic review and meta-analysis.

Jin Z1,2,3, Chen J1,2,3, Shu B1,2,3, Xiao Y4, Tang D5,6,7.

Author information

1
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
2
Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
3
Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, 200032, China.
4
Jinggangshan University, Ji'an, 343009, China. xyh20040701@126.com.
5
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. dzt702@163.com.
6
Institute of Spine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. dzt702@163.com.
7
Key Laboratory of Theory and Therapy of Muscles and Bones, Ministry of Education, Shanghai, 200032, China. dzt702@163.com.

Abstract

BACKGROUND:

Previous studies have found that bone mesenchymal stem cells (BMSCs) were capable of self-replication, multi-differentiation, and regeneration. The aim of this study was to carry out a systematic review and meta-analysis of the efficacy of BMSC therapy for ovariectomized rats.

METHODS:

The PubMed, Embase, Web of Science, China National Knowledge Infrastructure, VIP, and Chinese Sinomed databases were searched systematically from their initiation date to October 5, 2018. Two researchers independently screened the literatures, which used the bone mineral density (BMD), total bone volume by total tissue volume (BV/TV) (%), and trabecular thickness/spacing (Tb/Sp) as the outcome measures.

RESULTS:

Five eligible studies were selected. In the BMSC treatment groups, the BMD values and normalized BV/TV values remarkably increased. In addition, in the BMSCs plus other treatment groups, the BMD and Tb/Sp values significantly increased.

CONCLUSION:

This study showed that BMSCs could accelerate callus maturity, ossification and restore mechanical properties of bones in osteoporotic fractures.

KEYWORDS:

Bone mesenchymal stem cells; Fracture; Meta-analysis; Osteoporotic; Ovariectomy

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