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Phytother Res. 2019 Nov 20. doi: 10.1002/ptr.6538. [Epub ahead of print]

Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress.

Liu T1,2,3, Li N1,2,3,4, Yan YQ1,2,3, Liu Y5, Xiong K1,2,3, Liu Y6, Xia QM6, Zhang H1,2,3, Liu ZD1,2,3,4.

Author information

1
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
2
Laboratory of Pharmacology of TCM Formulae Co-Constructed by the Province-Ministry, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
3
Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
4
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
5
Information Center, Tianjin Polytechnic University, Tianjin, China.
6
Chinese Medical College, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Abstract

Skin undergoes degenerative changes as it ages, which include the loss of elasticity, reductions in the epidermal thickness and collagen content, elastic fiber degeneration, and increased wrinkling and dryness. Skin aging can be significantly delayed by the administration of estrogen. Estrogen deficiency following menopause results in atrophic skin changes and the acceleration of skin aging. Estrogen administration has positive effects on human skin by delaying or preventing skin aging manifestations, but the use of estrogen replacement is a risk factor for breast and uterine cancer. Phytoestrogens are a large family of plant-derived molecules possessing various degrees of estrogen-like activity; they exhibit agonist or antagonist estrogenic properties depending on the tissue. These molecules could be ideal candidates to combat skin aging and other detrimental effects of hypoestrogenism. In this paper, we review the effects of phytoestrogens on human skin and the mechanisms by which phytoestrogens can alleviate the changes due to aging.

KEYWORDS:

collagen; estrogen; oxidative stress; phytoestrogens; skin aging; water content

PMID:
31747092
DOI:
10.1002/ptr.6538

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