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Bioinformatics. 2019 Nov 20. pii: btz871. doi: 10.1093/bioinformatics/btz871. [Epub ahead of print]

TFmiR2: Constructing and analyzing disease-, tissue- and process-specific transcription factor and microRNA co-regulatory networks.

Author information

1
Center for Bioinformatics, Saarland University, Saarbrucken, Germany.
2
Graduate School of Computer Science, Saarland University.
3
Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University Medical Center, Rostock, Germany.
4
Department of Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany.

Abstract

TFmiR2 is a freely available web server for constructing and analyzing integrated TF and miRNA co-regulatory networks for human and mouse. TFmiR2 generates tissue- and biological process-specific networks for the set of deregulated genes and miRNAs provided by the user. Furthermore, the service can now identify key driver genes and miRNAs in the constructed networks by utilizing the graph theoretical concept of a MCDS. These putative key players as well as the newly implemented 4-node TF-miRNA motifs yield novel insights that may assist in developing new therapeutic approaches.

AVAILABILITY:

The TFmiR2 web server is available at http://service.bioinformatik.uni-saarland.de/tfmir2.

SUPPLEMENTARY INFORMATION:

Supplementary data are available at Bioinformatics online.

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