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Biomed Mater. 2019 Nov 19. doi: 10.1088/1748-605X/ab591d. [Epub ahead of print]

Electrospinning 3D bioactive glasses for wound healing.

Author information

1
Imperial College London, London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
2
UCL, London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
3
School of Dentistry, University of Birmingham, Birmingham, B15 2TT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
4
University of Warwick, Coventry, West Midlands, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
5
Nagoya Institute of Technology, Nagoya, Aichi, JAPAN.
6
School of Biomedical Sciences, University of Ulster, Coleraine, Londonderry, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
7
Royal Free Medical School, UCL, London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
8
Department of Materials, Imperial College London, London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Abstract

An electrospinning technique was used to produce three-dimensional (3D) bioactive glass fibrous scaffolds, in the SiO2-CaO system, for wound healing applications. Previously, it was thought that 3D cotton wool-like structures could only be produced when the sol contained calcium nitrate, implying that the Ca2+ and its electronic charge had a significant effect on the structure produced. Here, fibres with a 3D appearance were also electrospun from compositions containing only silica. A polymer binding agent was added to inorganic sol-gel solutions, enabling electrospinning prior to bioactive glass network formation and the polymer was removed by calcination. While the addition of Ca2+ contributes to the 3D morphology, here we show that other factors, such as relative humidity, play an important role in producing the 3D cotton-wool-like macrostructure of the fibres. A human dermal fibroblast cell line (CD-18CO) was exposed to dissolution products of the samples. Cell proliferation and metabolic activity tests were carried out and a VEGF ELISA showed a significant increase in VEGF production in cells exposed to the bioactive glass samples compared to control in DMEM. A novel SiO2-CaO nanofibrous scaffold was created that showed tailorable physical and dissolution properties, the control and composition of these release products are important for directing desirable wound healing interactions.

KEYWORDS:

3D cotton-wool-like; Bioactive glass; electrospinning; sol-gel; wound healing

PMID:
31746779
DOI:
10.1088/1748-605X/ab591d

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