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Curr Stem Cell Res Ther. 2019 Nov 19. doi: 10.2174/1574888X14666191119122159. [Epub ahead of print]

Effectiveness of Stem Cell Therapy in Treatment of Ovarian Disorders and Female Infertility: A Systematic Review.

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Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Laboratory for Translational Immunology (LTI), Universitair Medisch Centrum Utrecht, (UMCU), Utrecht, Netherlands.
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.



Infertility is a major problem worldwide. Various strategies are being used to develop better treatments for infertility. On trending, the strategy is stem cell therapy. In this study, the literature on stem cell therapy for ovarian disorders is summarized with analysis of current developments.


Different published studies on stem cell-based therapy for the treatment of various types of ovarian insufficiency and disorders such as Premature Ovarian Insufficiency (POI) in the affected female population in animal or human clinical studies systematically reviewed.


We monitored five databases, including PubMed, Cochrane, Embase, Scopus, and ProQuest. A comprehensive online search was done using including criteria targeting application of stem cells in animal models for menopause. Two independent reviewers carefully evaluated titles and abstracts of studies. The stem cell type, source, dosage, route of administration were highlighted in various POI animals models. Non-relevant and review articles were excluded.


648 published studies were identified during the initial comprehensive search process from which 41 were selected according to designed criteria. Based on our analysis, stem cells could accelerate ovarian tissues rejuvenation, regulate systemic sex-related hormones levels and eventually increase fertility rate.


The evidence suggests that stem cell-based therapies could be considered as an alternative modality to deal with women undergoing POI.


Infertility; Ovarian disorder; Ovarian tissue; Premature Ovarian Insufficiency; Stem cell therapy; Transplantation

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