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Nat Immunol. 2019 Dec;20(12):1603-1609. doi: 10.1038/s41590-019-0524-9. Epub 2019 Nov 19.

TSLP: from allergy to cancer.

Author information

1
Department of Medicine and Department of Pediatrics, Division of Allergy and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
2
Immunology Program, Benaroya Research Institute, Seattle, WA, USA. sziegler@benaroyaresearch.org.

Abstract

The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for TSLP in inflammatory diseases and cancer. In this Review, we will highlight major recent advances in TSLP biology, along with results from emerging clinical trials of anti-TSLP agents used for the treatment of a variety of inflammatory conditions.

PMID:
31745338
DOI:
10.1038/s41590-019-0524-9

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