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Neurol India. 2019 Sep-Oct;67(5):1358-1359. doi: 10.4103/0028-3886.271247.

An Investigation on the Coinfection of Measles and HSV-1 in Hospitalized Acute Encephalitis Syndrome Patients in Eastern India.

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Virology Division, ICMR-RMRC; Department of Biotechnology, School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
Virology Division, ICMR-RMRC; Department of Pediatrics, AIIMS, Bhubaneswar, Odisha, India.
Virology Division, ICMR-RMRC, Bhubaneswar, Odisha, India.
Department of Microbiology, Apollo Hospital, Bhubaneswar, Odisha, India.
IMS and SUM Hospital, Director, Medical Research and Life Sciences, Bhubaneswar, Odisha, India.


Acute encephalitis syndrome (AES) is a clinical condition that occurs due to infectious and noninfectious agents- however, viruses are considered to be the dominant pathogen. agents- however, viruses are considered to be the dominant pathogen. In this study, suspected AES cases were enrolled and tested for viral etiology through serology and polymerase chain reaction (PCR)/reverse transcriptase PCR from August 2012-July 2013. During this period, 820 cases were investigated and 96 cases were diagnosed to have a viral etiology whereas 20 patients had IgM antibodies for measles in serum and HSV-1 DNA in cerebrospinal fluid. All 20 of the patients were children below 14 years of age. The median hospital stay was 15 days (IQR: 14.2-17 days) and median GCS score was 7(IQR: 6-8) and were significantly different with patients with co-infections when comapred with patients having HSV-1 infection only. It may be suspected that the measles infection may have a role in the pathogenesis and thus an impact on the prognosis of the AES when present with HSV-1.


Acute encephalitis syndrome; dual infection; herpes simplex encephalitis; measles

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