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Nutrients. 2019 Nov 17;11(11). pii: E2808. doi: 10.3390/nu11112808.

The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines.

Author information

1
Department of Natural Sciences, School of Arts and Science, Lebanese American University, Beirut 1102-2801, Lebanon.
2
Department of Physiological Chemistry, University of Veterinary Medicine Hannover, 30559 Hannover, Germany.

Abstract

Acute myeloid leukemia (AML) is a blood cancer characterized by the formation of faulty defective myelogenous cells with morphological heterogeneity and cytogenic aberrations leading to a loss of their function. In an attempt to find an effective and safe AML treatment, vitamin E derivatives, including tocopherols were considered as potential anti-tumor compounds. Recently, other isoforms of vitamin E, namely tocotrienols have been proposed as potential potent anti-cancerous agents, displaying promising therapeutic effects in different cancer types. In this study we evaluated the anti-cancerous effects of γ-tocotrienol, on AML cell lines in vitro. For this purpose, AML cell lines incubated with γ-tocotrienol were examined for their viability, cell cycle status, apoptotic cell death, DNA fragmentation, production of reactive oxygen species and expression of proapoptotic proteins. Our results showed that γ-tocotrienol exhibits time and dose-dependent anti-proliferative, pro-apoptotic and antioxidant effects on U937 and KG-1 cell lines, through the upregulation of proteins involved in the intrinsic apoptotic pathway.

KEYWORDS:

apoptosis; gamma tocotrienols; leukemia; vitamin E

PMID:
31744219
DOI:
10.3390/nu11112808
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